Scientist now Using One Germ to Fight Another When Today's Antibiotics Fail

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Bacteria lodged deep in Ella Balasa's lungs were impervious to most antibiotics. At 26, gasping for breath, she sought out a dramatic experiment — deliberately inhaling a virus culled from sewage to attack her superbug.

"I'm really running out of options," said Balasa, who traveled from her Richmond, Virginia, home to Yale University for the last-resort treatment. "I know it might not have an effect. But I am very hopeful."

Pitting one germ against another may sound radical, but it's a sign of a growing global crisis. Increasingly people are dying of infections that once were easy to treat because many common bugs have evolved to withstand multiple antibiotics. Some, dubbed "nightmare bacteria," are untreatable. Now scientists are racing to find novel alternatives to traditional antibiotics, a hunt that is uncovering unusual ways to counter infection, in unusual places.

One possible treatment tricks bacteria out of a nutrient they need to survive. Others rev up the immune system to better fend off germs.

And viruses called bacteriophages — discovered a century ago but largely shelved in the West when easier-to-use antibiotics came along — are being tried in a handful of emergency cases.

"People's frustration with antibiotic resistance boiled over," said Yale biologist Benjamin Chan, who travels the world collecting phages and receives calls from desperate patients asking to try them. "We're more appreciative of the fact that we need alternatives."

Nature's bacterial predator, each phage variety targets a different bacterial strain. Originally used to treat dysentery in the early 20th century, today Chan looks in places like ditches, ponds, and, yes, sewage treatment plants for types that attack a variety of human infections.